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Nebulization allows exosomes to directly reach the alveolar surface and bronchioles, cross the mucus layer, and be specifically taken up by damaged epithelial cells, significantly increasing local drug concentration while avoiding the risk of metabolic inactivation associated with systemic administration ( At the mechanistic level, the therapeutic potential of MSC exosomes has transcended simple molecular delivery, extending into the field of organelle transplantation

With vastly lowered blood volume , your heart simply does not have enough fluid to fight gravity when you stand up

For patients with known comorbidities, medical clearance is needed before each session